Shore has written the music for such various major film productions as The Silence of the Lambs, Mrs. Doubtfire, Philadelphia, Ed Wood, Se7en, Dogma, High Fidelity, Panic Room, The Departed and The Aviator, the last of which earned him a Golden Globe. Since The Brood in 1979, he has been a consistent collaborator with David Cronenberg, scoring all his subsequent films except The Dead Zone (1983, scored by Michael Kamen). His score for Cronenberg's Naked Lunch is notable for his collaboration with famed avant-garde jazz musician Ornette Coleman, who praised Shore's work.